# Social Neuroscience Specific neurons and neurotransmitters such as nor-epinephrine, trigger a state that can be described as having an 'active ego' when we feel that our own thoughts have to be protected from the influence of others. If we are then confronted with differences in opinion, the chemicals that are released in the brain are the same ones that try to ensure our survival in dangerous situations. Sometimes debates go on endlessly because people keep expressively resisting differences in opinion. When we're in a defensive state, the more primitive part of the brain interferes with our rational thinking and the limbic system can even knock out most of our working memory, physically causing narrow mindedness. We see this in the politics of fear, the strategy of poker players or simply when people feel defensive and stubborn in discussions. No matter how valuable an idea is, the brain has trouble processing it when it is in such a state. On a neural level, it reacts as if our life is being threatened, even if the threat comes from harmless opinions or even facts that we may otherwise find helpful and could rationally agree on. But when we express ourselves and our views are appreciated, these defense chemicals decrease in the brain and dopamine neurotransmission activates the reward neurons, making us feel empowered and increasing our self-esteem. Our beliefs have a profound impact on our body chemistry, this is why placebos are so effective. Self-esteem or self-belief is closely linked to the neurotransmitter serotonin. A relative imbalance of it often leads to depression, self-destructive behaviour or even suicide. Social invalidation is the primary cause of this while validation has the opposite effect: Social validation increases the levels of dopamine and serotonin in the brain and allows us to let go of emotional fixations and become self-aware more easily.